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Article

The Epac2 coding gene (RAPGEF4) rs3769219 polymorphism is associated with protection against major depressive disorder in the Chinese Han population.

Neuroscience letters - 1 Nov 2020

Peng Qiuju, Kong Yanying, Shi Lei, Yan Yuan, Yao Yuan, Wen Yuguan, Liang Yumin, Lai Chongfa, Deng Zhirong, Yan Huacheng

Abstract excerpt

BACKGROUND: Adult hippocampal neurogenesis has been demonstrated to be associated with the occurrence of major depressive disorder (MDD). A recent study indicated that deletion of the Epac2 gene (RAPGEF4) caused downregulation of hippocampal neurogenesis. This study aimed to analyze the association between genetic variants of the RAPGEF4 gene and the risk of MDD. METHODS: We recruited 502 patients with MDD and...

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PMID: 32905835
DOI: 10.1016/j.neulet.2020.135361

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