Article
Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression.
Molecular psychiatry - 1 Aug 2021
Forstner Andreas J, Awasthi Swapnil, Wolf Christiane, Maron Eduard, Erhardt Angelika, Czamara Darina, Eriksson Elias, Lavebratt Catharina, Allgulander Christer, Friedrich Nina, Becker Jessica, Hecker Julian, Rambau Stefanie, Conrad Rupert, Geiser Franziska, McMahon Francis J, Moebus Susanne, Hess Timo, Buerfent Benedikt C, Hoffmann Per, Herms Stefan, Heilmann-Heimbach Stefanie, Kockum Ingrid, Olsson Tomas, Alfredsson Lars, Weber Heike, Alpers Georg W, Arolt Volker, Fehm Lydia, Fydrich Thomas, Gerlach Alexander L, Hamm Alfons, Kircher Tilo, Pané-Farré Christiane A, Pauli Paul, Rief Winfried, Ströhle Andreas, Plag Jens, Lang Thomas, Wittchen Hans-Ulrich, Mattheisen Manuel, Meier Sandra, Metspalu Andres, Domschke Katharina, Reif Andreas, Hovatta Iiris, Lindefors Nils, Andersson Evelyn, Schalling Martin, Mbarek Hamdi, Milaneschi Yuri, de Geus Eco J C, Boomsma Dorret I, Penninx Brenda W J H, Thorgeirsson Thorgeir E, Steinberg Stacy, Stefansson Kari, Stefansson Hreinn, Müller-Myhsok Bertram, Hansen Thomas Folkmann, Børglum Anders D, Werge Thomas, Mortensen Preben Bo, Nordentoft Merete, Hougaard David M, Hultman Christina M, Sullivan Patrick F, Nöthen Markus M, Woldbye David P D, Mors Ole, Binder Elisabeth B, Rück Christian, Ripke Stephan, Deckert Jürgen, Schumacher Johannes
Abstract excerpt
Panic disorder (PD) has a lifetime prevalence of 2-4% and heritability estimates of 40%. The contributory genetic variants remain largely unknown, with few and inconsistent loci having been reported. The present report describes the largest genome-wide association study (GWAS) of PD to date comprising genome-wide genotype data of 2248 clinically well-characterized PD patients and 7992 ethnically matched controls....
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