Article
Gender-specific association of variants in the AKR1C1 gene with dimensional anxiety in patients with panic disorder: additional evidence for the importance of neurosteroids in anxiety?
Depression and anxiety - 1 Oct 2014
Quast Carina, Reif Andreas, Brückl Tanja, Pfister Hildegard, Weber Heike, Mattheisen Manuel, Cichon Sven, Lang Thomas, Hamm Alfons, Fehm Lydia, Ströhle Andreas, Arolt Volker, Domschke Katharina, Kircher Tilo, Wittchen Hans-Ulrich, Pauli Paul, Gerlach Alexander L, Alpers Georg W, Deckert Jürgen, Rupprecht Rainer, Binder Elisabeth B, Erhardt Angelika
Abstract excerpt
BACKGROUND: Neurosteroids are synthesized both in brain and peripheral steroidogenic tissue from cholesterol or steroidal precursors. Neurosteroids have been shown to be implicated in neural proliferation, differentiation, and activity. Preclinical and clinical studies also suggest a modulatory role of neurosteroids in anxiety-related phenotypes. However, little is known about the contribution of genetic variants...
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