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Article

Antidepressive-drug-induced bodyweight gain is associated with polymorphisms in genes coding for COMT and TPH1.

International clinical psychopharmacology - 1 Jul 2009

Secher Anna, Bukh Jens, Bock Camilla, Koefoed Pernille, Rasmussen Henrik Berg, Werge Thomas, Kessing Lars Vedel, Mellerup Erling

Abstract excerpt

Bodyweight gain is a common side effect of treatment with antidepressive drugs; however, little is known about the mechanisms behind this weight gain. Genetic differences may contribute to the susceptibility for bodyweight gain during antidepressive treatment. The objective of this study was to examine the association of antidepressive-drug-induced bodyweight gain with polymorphisms in genes within the serotonin...

Read the complete abstract on PubMed

Topics

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Share to Antidepressive Agents
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depression

Share to Polymorphism, Genetic

Share to Receptor, Serotonin, 5-HT2C

Share to Serotonin Plasma Membrane Transport Proteins

Share to Tryptophan Hydroxylase

Share to Weight Gain

Source

Identifiers

PMID: 19474754
DOI: 10.1097/YIC.0b013e32832d6be2

Genes

TPH1
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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