Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism.

Lancet (London, England) - 15 Jun 2002

Reynolds Gavin P, Zhang Zhi-Jun, Zhang Xiao-Bin

Abstract excerpt

A side-effect of treatment with antipsychotic drugs for schizophrenia is increased body fat, which leads to further morbidity and poor adherence to treatment. The 5-hydroxytryptamine 2C receptor (5-HT2C) has been associated with this effect; we aimed to establish whether a genetic polymorphism of the promoter region of this receptor affects weight gain after drug treatment in first-episode patients with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Antipsychotic Agents
Share to Body Mass Index

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Polymorphism, Genetic

Share to Receptor, Serotonin, 5-HT2C

Share to Receptors, Serotonin

Share to Schizophrenia

Share to Weight Gain

Source

Identifiers

PMID: 12086765
DOI: 10.1016/S0140-6736(02)08913-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism.PMID 12086765Read ↗

Role of 5-HT2C receptor gene variants in antipsychotic-induced weight gainSemantic proximity Read ↗

Polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene and clozapine-induced weight gain.Semantic proximity Read ↗

Polymorphisms of the HTR2C gene and antipsychotic-induced weight gain: an update and meta-analysis.Semantic proximity Read ↗

Weight gain with antipsychotic drugs: the role of the 5-HT2C receptor (HTR2C) and other genes.Semantic proximity Read ↗

-759C>T Polymorphism of the HTR2C Gene is Associated with Second Generation Antipsychotic-Induced Weight Gain in Female Patients with Schizophrenia.Semantic proximity Read ↗

Association of the HTR2C gene and antipsychotic induced weight gain: a meta-analysis.Semantic proximity Read ↗

Clozapine-induced weight gain associated with the 5HT2C receptor -759C/T polymorphism.Semantic proximity Read ↗

Pharmacogenetic Aspects of Antipsychotic Drug-induced Weight Gain - A Critical ReviewSemantic proximity Read ↗

Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis.Semantic proximity Read ↗

Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene.Semantic proximity Read ↗

Lack of association between the -759C/T polymorphism of the 5-HT2C receptor gene and clozapine-induced weight gain among German schizophrenic individuals.Semantic proximity Read ↗

-759 C/T polymorphism of 5-HT2C receptor gene and early phase weight gain associated with antipsychotic drug treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.