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Article

Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism.

Lancet (London, England) - 15 Jun 2002

Reynolds Gavin P, Zhang Zhi-Jun, Zhang Xiao-Bin

Abstract excerpt

A side-effect of treatment with antipsychotic drugs for schizophrenia is increased body fat, which leads to further morbidity and poor adherence to treatment. The 5-hydroxytryptamine 2C receptor (5-HT2C) has been associated with this effect; we aimed to establish whether a genetic polymorphism of the promoter region of this receptor affects weight gain after drug treatment in first-episode patients with...

Topics

Adipose Tissue
Adult
Antipsychotic Agents
Body Mass Index
Female
Genotype
Humans
Male
Polymorphism, Genetic
Receptor, Serotonin, 5-HT2C
Receptors, Serotonin
Schizophrenia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Weight Gain

Source

Identifiers

PMID: 12086765
DOI: 10.1016/S0140-6736(02)08913-4

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Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism.PMID 12086765Read ↗

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