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Article

BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancer.

British journal of cancer - 1 Mar 2011

Yokota T, Ura T, Shibata N, Takahari D, Shitara K, Nomura M, Kondo C, Mizota A, Utsunomiya S, Muro K, Yatabe Y

Abstract excerpt

BACKGROUND: Activating mutation of KRAS and BRAF are focused on as potential prognostic and predictive biomarkers in patients with colorectal cancer (CRC) treated with anti-EGFR therapies. This study investigated the clinicopathological features and prognostic impact of KRAS/BRAF mutation in advanced and recurrent CRC patients. METHOD: Patients with advanced and recurrent CRC treated with systemic chemotherapy...

Topics

Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Colorectal Neoplasms
Female
Genes, ras
Humans
Male
Middle Aged
Mutation
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins B-raf

Recurrence

Source

Open in PubMed Open full text

Identifiers

PMID: 21285991
DOI: 10.1038/bjc.2011.19
PMCID: PMC3048210

Genes

BRAF
KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21285991-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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