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Article

Concomitant KRAS and BRAF mutations in colorectal cancer

9 May 2019

Abstract excerpt

Abstract: BRAF and KRAS are two key oncogenes in the RAS/RAF/MEK/MAP-kinase signaling pathway. While previously considered mutually exclusive, concomitant mutations in both KRAS and BRAF genes have been identified in colorectal cancer (CRC). The clinical outcome of these patients remains undetermined. We present the clinical course of two patients with CRC harboring mutations at codon 12 of KRAS and BRAF...

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PMID: 31183211
DOI: 10.21037/jgo.2019.01.10

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