Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuroinvasion in sheep transmissible spongiform encephalopathies: the role of the haematogenous route.

Neuropathology and applied neurobiology - 1 Jun 2009

Sisó S, Jeffrey M, González L

Abstract excerpt

BACKGROUND: It is generally believed that after oral exposure to transmissible spongiform encephalopathy (TSE) agents, neuroinvasion occurs via the enteric nervous system (ENS) and the autonomic nervous system. As a result, the dorsal motor nucleus of the vagus nerve is the initial point of disease-associated prion protein (PrP(d)) accumulation in the brain. HYPOTHESIS AND AIM: If direct ENS invasion following...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood-Brain Barrier
Share to Cerebral Ventricles
Share to Enteric Nervous System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypothalamus

Share to Prion Diseases

Share to PrPSc Proteins

Share to Scrapie

Share to Vagus Nerve

Source

Identifiers

PMID: 19473292
DOI: 10.1111/j.1365-2990.2008.00978.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuroinvasion in sheep transmissible spongiform encephalopathies: the role of the haematogenous route.PMID 19473292Read ↗

Identical pathogenesis and neuropathological phenotype of scrapie in valine, arginine, glutamine/valine, arginine, glutamine sheep infected experimentally by the oral and conjunctival routes.Semantic proximity Read ↗

Neuroinvasion in Prion Diseases: The Roles of Ascending Neural Infection and Blood DisseminationSemantic proximity Read ↗

Autonomic nervous system innervation of lymphoid territories in spleen: a possible involvement of noradrenergic neurons for prion neuroinvasion in natural scrapie.Semantic proximity Read ↗

Early accumulation of PrP(Sc) in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie.Semantic proximity Read ↗

Distribution of the prion protein in sheep terminally affected with BSE following experimental oral transmission.Semantic proximity Read ↗

Phenotype of disease-associated PrP accumulation in the brain of bovine spongiform encephalopathy experimentally infected sheep.Semantic proximity Read ↗

PrP(Sc) deposition in nervous tissues without lymphoid tissue involvement is frequently found in ARQ/ARQ Sarda breed sheep preclinically affected with natural scrapie.Semantic proximity Read ↗

Influence of breed and genotype on the onset and distribution of infectivity and disease-associated prion protein in sheep following oral infection with the bovine spongiform encephalopathy agent.Semantic proximity Read ↗

Diagnosis of preclinical scrapie in live sheep by the immunohistochemical examination of rectal biopsies.Semantic proximity Read ↗

Atypical/Nor98 scrapie infectivity in sheep peripheral tissues.Semantic proximity Read ↗

Accumulation of pathogenic prion protein (PrPSc) in nervous and lymphoid tissues of sheep with subclinical scrapie.Semantic proximity Read ↗

Detection of PrP(Sc) in rectal biopsy and necropsy samples from sheep with experimental scrapie.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.