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Article

The Notochordal Cell in the Nucleus Pulposus: A Review in the Context of Tissue Engineering

1 Aug 2003

Abstract excerpt

An understanding of developmental biology can provide useful insights into how different tissue-engineered repairs might be designed. During embryogenesis of the intervertebral disk, the cells of the notochord play a critical role in initiating tissue formation, and may be responsible for development of the nucleus pulposus. In some species, including humans, these notochordal cells may eventually be lost, either...

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PMID: 13678445
DOI: 10.1089/107632703768247368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The Notochordal Cell in the Nucleus Pulposus: A Review in the Context of Tissue EngineeringPMID 13678445Read ↗

Toward an understanding of the role of notochordal cells in the adult intervertebral disc: From discord to accordSemantic proximity Read ↗

An understanding of intervertebral disc development, maturation and cell phenotype provides clues to direct cell-based tissue regeneration therapies for disc degeneration.Semantic proximity Read ↗

Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation.Semantic proximity Read ↗

Getting to the Core: Exploring the Embryonic Development from Notochord to Nucleus PulposusSemantic proximity Read ↗

Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc RegenerationSemantic proximity Read ↗

Tracing notochord-derived cells using a <i>Noto-cre</i> mouse: implications for intervertebral disc developmentSemantic proximity Read ↗

Intervertebral disc repair and regeneration: Insights from the notochordSemantic proximity Read ↗

Understanding embryonic development for cell‐based therapies of intervertebral disc degeneration: Toward an effort to treat disc degeneration subphenotypesSemantic proximity Read ↗

Coming together is a beginning: The making of an intervertebral discSemantic proximity Read ↗

Differentiation of intervertebral notochordal cells through live automated cell imaging system in vitro.Semantic proximity Read ↗

Derivation of notochordal cells from human embryonic stem cells reveals unique regulatory networks by single cell‐transcriptomicsSemantic proximity Read ↗

Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degenerationSemantic proximity Read ↗

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