Article
The Notochordal Cell in the Nucleus Pulposus: A Review in the Context of Tissue Engineering
1 Aug 2003
Abstract excerpt
An understanding of developmental biology can provide useful insights into how different tissue-engineered repairs might be designed. During embryogenesis of the intervertebral disk, the cells of the notochord play a critical role in initiating tissue formation, and may be responsible for development of the nucleus pulposus. In some species, including humans, these notochordal cells may eventually be lost, either...