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Article

How new advances in genetic analysis are influencing the understanding and treatment of childhood acute leukemia.

Current opinion in pediatrics - 1 Feb 2011

Roberts Kathryn G, Mullighan Charles G

Abstract excerpt

PURPOSE OF REVIEW: This review describes the recent advances in genomic profiling that have provided critical new insights into the biology of acute leukemia in children. RECENT FINDINGS: Acute leukemia genomes commonly harbor submicroscopic gains and deletions of DNA which target key cellular pathways that influence leukemogenesis and the likelihood of treatment failure, particularly in acute lymphoblastic...

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Source

Identifiers

PMID: 21169835
DOI: 10.1097/MOP.0b013e3283426260

Genes

CRLF2
IKZF1
JAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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