Functional impact of endotoxin receptor CD14 polymorphisms on transcriptional activity.

doi:10.1007/s00109-009-0479-7

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Article

Functional impact of endotoxin receptor CD14 polymorphisms on transcriptional activity.

Journal of molecular medicine (Berlin, Germany) - 1 Aug 2009

Mertens Jasmin, Bregadze Rusudan, Mansur Ashham, Askar Eva, Bickeböller Heike, Ramadori Giuliano, Mihm Sabine

Abstract excerpt

The polymorphism rs2569190 within the CD14 endotoxin (lipopolysaccharide, LPS) receptor gene is associated with various disease conditions that are assumed to rely on endotoxin sensitivity. In vitro experiments suggest that the T allele sensitizes the host for exogenous or endogenous LPS via an enhanced CD14 expression. To prove the impact of this single nucleotide polymorphism in its natural genomic context in...

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PMID: 19468702
DOI: 10.1007/s00109-009-0479-7
PMCID: PMC2707953

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