Article
Promoter polymorphism in the endotoxin receptor (CD14) is associated with increased carotid atherosclerosis only in smokers: the Carotid Atherosclerosis Progression Study (CAPS).
Stroke - 1 Mar 2003
Risley Paul, Jerrard-Dunne Paula, Sitzer Matthias, Buehler Alexandra, von Kegler Stefan, Markus Hugh S
Abstract excerpt
BACKGROUND AND PURPOSE: The risk of atherosclerosis from endotoxemia is increased in smokers. Endotoxin is a potent mediator of inflammation, and smokers have elevated plasma levels of endotoxin. The endotoxin receptor CD14 can enhance the endotoxin-neutralization capacity of plasma. A functional polymorphism in the promoter region of the CD14 gene (CD14 -159C/T) was studied to determine its impact on common...
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