Article
Association between manganese superoxide dismutase (MnSOD) Val-9Ala polymorphism and cancer risk - A meta-analysis.
European journal of cancer (Oxford, England : 1990) - 1 Nov 2009
Wang Sumin, Wang Furu, Shi Xiaoyan, Dai Juncheng, Peng Yuzhu, Guo Xirong, Wang Xinru, Shen Hongbing, Hu Zhibin
Abstract excerpt
A growing body of evidence suggests that reactive oxygen species (ROS) play an important role in human cancers. Manganese superoxide dismutase (MnSOD) is the major antioxidant in the mitochondria, catalysing the dismutation of superoxide radicals to form hydrogen peroxide. Since the identification of a well-characterised functional polymorphism, Val-9Ala of MnSOD, a number of molecular epidemiological studies...
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