Article
Analysis of the spontaneous mutator phenotype associated with 20S proteasome deficiency in S. cerevisiae.
Mutation research - 29 Jan 2006
McIntyre Justyna, Podlaska Agnieszka, Skoneczna Adrianna, Halas Agnieszka, Sledziewska-Gojska Ewa
Abstract excerpt
Besides its role as a major recycler of unfolded or otherwise damaged intracellular proteins, the 26S proteasome functions as a regulator of many vital cellular processes and is postulated as a target for antitumor drugs. It has previously been shown that dysfunction of the catalytic core of the...
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