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Article

The impact of UGT2B7 C802T and CYP3A4*1G polymorphisms on pain relief in cancer patients receiving oxycontin.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer - 1 Aug 2018

Li Jingwen, Peng Peng, Mei Qi, Xia Shu, Tian Yijun, Hu Liya, Chen Yuan

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms (SNPs) in UGT2B7 C802T and CYP3A4*1G impact drug metabolism. This study aimed to investigate the impact of these SNPs on the efficacy of oxycontin for pain relief in cancer patients. METHODS: A total of 57 Han Chinese cancer patients (age range 20-70 years) who received oxycontin to ease pain for the first time were enrolled and divided into two groups (refractory group...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29502154
DOI: 10.1007/s00520-018-4130-4

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