Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The changing landscape of Lynch syndrome due to PMS2 mutations.

Clinical genetics - 1 Jul 2018

Blount J, Prakash A

Abstract excerpt

DNA repair pathways are essential for cellular survival as our DNA is constantly under assault from both exogenous and endogenous DNA damaging agents. Five major mammalian DNA repair pathways exist within a cell to maintain genomic integrity. Of these, the DNA mismatch repair (MMR) pathway is highly conserved among species and is well documented in bacteria. In humans, the importance of MMR is underscored by the...

Topics

Join the communities discussing this publication.

Alleles
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Mismatch Repair
Genetic Association Studies
Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mismatch Repair Endonuclease PMS2

Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 29286535
DOI: 10.1111/cge.13205
PMCID: PMC5995637

Genes

PMS2
MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The changing landscape of Lynch syndrome due to PMS2 mutations.PMID 29286535Read ↗

New Insights into Lynch Syndrome: A Narrative Review.Semantic proximity Read ↗

Update on Lynch syndrome genomics.Semantic proximity Read ↗

Lynch syndrome in the 21st century: clinical perspectives.Semantic proximity Read ↗

Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndromeSemantic proximity Read ↗

Cancer risks in Lynch syndrome carriers: a systematic review and meta-analysis.Semantic proximity Read ↗

DNA mismatch repair proteins: scientific update and practical guide.Semantic proximity Read ↗

Colorectal cancer in Lynch syndrome associated with PMS2 and MSH6 mutations.Semantic proximity Read ↗

Recent advances in Lynch syndromeSemantic proximity Read ↗

Mismatch repair deficiency testing in clinical practiceSemantic proximity Read ↗

Lynch syndrome and colorectal cancer: A review of current perspectives in molecular genetics and clinical strategiesSemantic proximity Read ↗

Current clinical topics of Lynch syndrome.Semantic proximity Read ↗

Review article: Lynch Syndrome—a mechanistic and clinical management updateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.