Article
2-Phenethyl Isothiocyanate, Glutathione S-transferase M1 and T1 Polymorphisms, and Detoxification of Volatile Organic Carcinogens and Toxicants in Tobacco Smoke.
Cancer prevention research (Philadelphia, Pa.) - 1 Jul 2016
Yuan Jian-Min, Murphy Sharon E, Stepanov Irina, Wang Renwei, Carmella Steven G, Nelson Heather H, Hatsukami Dorothy, Hecht Stephen S
Abstract excerpt
Cigarette smoke contains relatively large quantities of volatile organic toxicants or carcinogens such as benzene, acrolein, and crotonaldehyde. Among their detoxification products are mercapturic acids formed from glutathione conjugation, catalyzed in part by glutathione S-transferases (GST). A randomized phase II clinical trial with a crossover design was conducted to evaluate the effect of 2-phenethyl...
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