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Article

The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body-P body pathway.

Developmental biology - 1 Aug 2009

Lee Lin, Davies Siân E, Liu Ji-Long

Abstract excerpt

Survival motor neuron protein (SMN) is the determining factor for the human neurodegenerative disease spinal muscular atrophy (SMA). SMN is critical for small nuclear ribonucleoprotein (snRNP) assembly. Using Drosophila oogenesis as a model system, we show that mutations in smn cause abnormal nuclear organization in nurse cells and oocytes. Germline and mitotic clonal analysis reveals that both nurse cells and...

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Identifiers

PMID: 19464282
DOI: 10.1016/j.ydbio.2009.05.553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body-P body pathway.PMID 19464282Read ↗

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