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Article

The Spinal Muscular Atrophy Disease Gene Product, Smn

15 Nov 1999

Abstract excerpt

The spliceosomal snRNAs U1, U2, U4, and U5 are synthesized in the nucleus, exported to the cytoplasm to assemble with Sm proteins, and reimported to the nucleus as ribonucleoprotein particles. Recently, two novel proteins involved in biogenesis of small nuclear ribonucleoproteins (snRNPs) were identified, the Spinal muscular atrophy disease gene product (SMN) and its associated protein SIP1. It was previously...

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PMID: 10562276
DOI: 10.1083/jcb.147.4.715

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