Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SMN and Gemins: ‘We are family’ … or are we?

15 Oct 2010

Abstract excerpt

Gemins 2-8 and Unr-interacting protein (UNRIP) are intimate partners of the survival motor neuron (SMN) protein, which is the determining factor for the neuromuscular disorder spinal muscular atrophy (SMA). The most documented role of SMN, Gemins and UNRIP occurs within the large macromolecular SMN complex and involves the cytoplasmic assembly of spliceosomal uridine-rich small nuclear ribonucleoproteins...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neurogenetic and Muscular Disorders Research
Share to RNA modifications and cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20954180
DOI: 10.1002/bies.201000088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SMN and Gemins: ‘We are family’ … or are we?PMID 20954180Read ↗

A Comprehensive Interaction Map of the Human Survival of Motor Neuron (SMN) ComplexSemantic proximity Read ↗

Gemin8 Is a Novel Component of the Survival Motor Neuron Complex and Functions in Small Nuclear Ribonucleoprotein AssemblySemantic proximity Read ↗

Emerging Roles of Gemin5: From snRNPs Assembly to Translation ControlSemantic proximity Read ↗

Gemins modulate the expression and activity of the SMN complexSemantic proximity Read ↗

Disruption of snRNP biogenesis factors Tgs1 and pICln induces phenotypes that mirror aspects of SMN-Gemins complex perturbation in Drosophila, providing new insights into spinal muscular atrophy.Semantic proximity Read ↗

Spinal Muscular Atrophy: From Defective Chaperoning of snRNP Assembly to Neuromuscular DysfunctionSemantic proximity Read ↗

The Gemin associates of survival motor neuron are required for motor function in Drosophila.Semantic proximity Read ↗

Spliceosomal small nuclear ribonucleoprotein biogenesis defects and motor neuron selectivity in spinal muscular atrophy.Semantic proximity Read ↗

SMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediate.Semantic proximity Read ↗

Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteinsSemantic proximity Read ↗

Gemin4Semantic proximity Read ↗

Gemin5, a Novel WD Repeat Protein Component of the SMN Complex That Binds Sm ProteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.