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Article

Effects of partial suppression of parkin on huntingtin mutant R6/1 mice.

Brain research - 24 Jul 2009

Rubio Isabel, Rodríguez-Navarro José Antonio, Tomás-Zapico Cristina, Ruíz Carolina, Casarejos María José, Perucho Juan, Gómez Ana, Rodal Izaskun, Lucas José J, Mena María Angeles, de Yébenes Justo García

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder caused by an expansion of polyglutamines which makes huntingtin more resistant to degradation. Parkin is an ubiquitin ligase which promotes proteosomal degradation of abnormal proteins. We investigated whether partial suppression of parkin increases HD phenotype. We studied the behavior and brain histology and biochemistry of the mice produced by...

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Source

Identifiers

PMID: 19464273
DOI: 10.1016/j.brainres.2009.05.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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