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Article

Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice.

Human molecular genetics - 15 Oct 2008

Rodríguez-Navarro Jose A, Gómez Ana, Rodal Izaskun, Perucho Juan, Martinez Armando, Furió Vicente, Ampuero Israel, Casarejos María J, Solano Rosa M, de Yébenes Justo García, Mena Maria A

Abstract excerpt

Deposition of proteins leading to amyloid takes place in some neurodegenerative diseases such as Alzheimer's disease and Huntington's disease. Mutations of tau and parkin proteins produce neurofibrillary abnormalities without deposition of amyloid. Here we report that mature, parkin null, over-ex...

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Identifiers

PMID: 18640988
DOI: 10.1093/hmg/ddn210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18640988-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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