Article
Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice.
Cell death and differentiation - 1 Jun 2006
Candi E, Rufini A, Terrinoni A, Dinsdale D, Ranalli M, Paradisi A, De Laurenzi V, Spagnoli L G, Catani M V, Ramadan S, Knight R A, Melino G
Abstract excerpt
Epidermal development requires the transcription factor p63, as p63-/- mice are born dead, without skin. The gene expresses two proteins, one with an amino-terminal transactivation domain (TAp63) and one without (deltaNp63), although their relative contribution to epidermal development is unknown. To address this issue, we reintroduced TAp63alpha and/or deltaNp63alpha under the K5 promoter into p63-/- mice by in...
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