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Article

One base pair change abolishes the T cell-restricted activity of a kB-like proto-enhancer element from the interleukin 2 promoter.

Nucleic acids research - 11 Nov 1991

Briegel K, Hentsch B, Pfeuffer I, Serfling E

Abstract excerpt

The inducible, T cell-specific enhancers of murine and human Interleukin 2 (Il-2) genes contain the kB-like sequence GGGATTTCACC as an essential cis-acting enhancer motif. When cloned in multiple copies this so-called TCEd (distal T cell element) acts as an inducible proto-enhancer element in E14 T lymphoma cells, but not in HeLa cells. In extracts of induced, Il-2 secreting El4 cells three individual protein...

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Identifiers

PMID: 1945879
DOI: 10.1093/nar/19.21.5929
PMCID: PMC329049

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Source receipt: pubmed, retrieved 7 Sept 2026.

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