Article
One base pair change abolishes the T cell-restricted activity of a kB-like proto-enhancer element from the interleukin 2 promoter.
Nucleic acids research - 11 Nov 1991
Briegel K, Hentsch B, Pfeuffer I, Serfling E
Abstract excerpt
The inducible, T cell-specific enhancers of murine and human Interleukin 2 (Il-2) genes contain the kB-like sequence GGGATTTCACC as an essential cis-acting enhancer motif. When cloned in multiple copies this so-called TCEd (distal T cell element) acts as an inducible proto-enhancer element in E14 T lymphoma cells, but not in HeLa cells. In extracts of induced, Il-2 secreting El4 cells three individual protein...
Topics
- Animals
- Base Composition
- Chloramphenicol O-Acetyltransferase
- Cloning, Molecular
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- HeLa Cells
- Hepatocyte Nuclear Factor 1-alpha
- Humans
- Interleukin-2