Article
A sequencing-based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controls.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2010
Amin Zenab, Kanarek Katarzyna, Krupitsky Evgeny, Walderhaug Espen, Ilomäki Risto, Blumberg Hilary, Price Lawrence H, Bhagwagar Zubin, Carpenter Linda L, Tyrka Audrey R, Magnusson Andres, Landrø Nils Inge, Zvartau Edwin, Gelernter Joel, Epperson C Neill, Räsänen Pirkko, Siironen Jari, Lappalainen Jaakko
Abstract excerpt
Rare apoptosis-promoting functional variants in the apoptosis protease activating factor 1 (APAF1) gene were recently reported to co-segregate with major depression in male members of families from Utah. In order to estimate the impact of these variants on risk for major depressive disorder (MDD) in the general population, we surveyed the frequency of the APAF1 putative MDD risk alleles using re-sequencing in a...
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