Article
Variants in Apaf-1 segregating with major depression promote apoptosome function.
Molecular psychiatry - 1 Jan 2006
Harlan J, Chen Y, Gubbins E, Mueller R, Roch J-M, Walter K, Lake M, Olsen T, Metzger P, Dorwin S, Ladror U, Egan D A, Severin J, Johnson R W, Holzman T F, Voelp K, Davenport C, Beck A, Potter J, Gopalakrishnan M, Hahn A, Spear B B, Halbert D N, Sullivan J P, Abkevich V, Neff C D, Skolnick M H, Shattuck D, Katz D A
Abstract excerpt
APAF1, encoding the protein apoptosis protease activating factor 1 (Apaf-1), has recently been established as a chromosome 12 gene conferring predisposition to major depression in humans. The molecular phenotypes of Apaf-1 variants were determined by in vitro reconstruction of the apoptosome complex in which Apaf-1 activates caspase 9 and thus initiates a cascade of proteolytic events leading to apoptotic...
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