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Article

Functional Expression of Two KvLQT1-related Potassium Channels Responsible for an Inherited Idiopathic Epilepsy

1 Jul 1998

Abstract excerpt

Benign familial neonatal convulsions (BFNC), a class of idiopathic generalized epilepsy, is an autosomal dominantly inherited disorder of newborns. BFNC has been linked to mutations in two putative K+ channel genes, KCNQ2 and KCNQ3. Amino acid sequence comparison reveals that both genes share strong homology to KvLQT1, the potassium channel encoded by KCNQ1, which is responsible for over 50% of inherited long QT...

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PMID: 9677360
DOI: 10.1074/jbc.273.31.19419

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Functional Expression of Two KvLQT1-related Potassium Channels Responsible for an Inherited Idiopathic EpilepsyPMID 9677360Read ↗

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