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Article

Benign familial neonatal convulsions caused by altered gating of KCNQ2/KCNQ3 potassium channels.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jan 2002

Castaldo Pasqualina, del Giudice Emanuele Miraglia, Coppola Giangennaro, Pascotto Antonio, Annunziato Lucio, Taglialatela Maurizio

Abstract excerpt

The muscarinic-regulated potassium current (M-current), formed by the heteromeric assembly of subunits encoded by the KCNQ2 and KCNQ3 genes, is a primary regulator of neuronal excitability; this regulation is accomplished by impeding repetitive firing and causing spike-frequency adaptation. Mutations in KCNQ2 or KCNQ3 cause benign familial neonatal convulsions (BFNC), a rare autosomal-dominant generalized...

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Source

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Identifiers

PMID: 11784811
PMCID: PMC6758678

Genes

KCNQ2
KCNQ3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Benign familial neonatal convulsions caused by altered gating of KCNQ2/KCNQ3 potassium channels.PMID 11784811Read ↗

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A reduced K+ current due to a novel mutation in KCNQ2 causes neonatal convulsions.Semantic proximity Read ↗

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KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum.Semantic proximity Read ↗

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Functional analysis of novel KCNQ2 and KCNQ3 gene variants found in a large pedigree with benign familial neonatal convulsions (BFNC).Semantic proximity Read ↗

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