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Article

Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: investigation of borate preservation.

Analytical chemistry - 15 Jun 2009

Smith Leon M, Maher Anthony D, Want Elizabeth J, Elliott Paul, Stamler Jeremiah, Hawkes Geoffrey E, Holmes Elaine, Lindon John C, Nicholson Jeremy K

Abstract excerpt

Borate is an antibacterial preservative widely used in clinical and large-scale epidemiological studies involving urine sample analysis. Since it readily forms covalent adducts and reversible complexes with hydroxyl and carboxylate groups, the effects of borate preservation in (1)H NMR-spectroscopy-based metabolic profiling of human urine samples have been assessed. Effects of various concentrations of borate...

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Identifiers

PMID: 19453167
DOI: 10.1021/ac9004875
PMCID: PMC2721977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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