Article
Assessment of metabolic phenotypic variability in children's urine using 1H NMR spectroscopy.
Scientific reports - 19 Apr 2017
Maitre Léa, Lau Chung-Ho E, Vizcaino Esther, Robinson Oliver, Casas Maribel, Siskos Alexandros P, Want Elizabeth J, Athersuch Toby, Slama Remy, Vrijheid Martine, Keun Hector C, Coen Muireann
Abstract excerpt
The application of metabolic phenotyping in clinical and epidemiological studies is limited by a poor understanding of inter-individual, intra-individual and temporal variability in metabolic phenotypes. Using 1H NMR spectroscopy we characterised short-term variability in urinary metabolites measured from 20 children aged 8-9 years old. Daily spot morning, night-time and pooled (50:50 morning and night-time)...
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