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Article

Aberrant trafficking of human melanocortin 1 receptor variants associated with red hair and skin cancer: Steady-state retention of mutant forms in the proximal golgi.

Journal of cellular physiology - 1 Sept 2009

Sánchez-Laorden Berta L, Herraiz Cecilia, Valencia Julio C, Hearing Vincent J, Jiménez-Cervantes Celia, García-Borrón José C

Abstract excerpt

The melanocortin 1 receptor (MC1R), a Gs protein-coupled receptor (GPCR) expressed in melanocytes, is a major determinant of skin pigmentation and phototype. MC1R activation stimulates melanogenesis and increases the ratio of black, strongly photoprotective eumelanins to reddish, poorly photoprotective pheomelanins. Several MC1R alleles are associated with red hair, fair skin, increased sensitivity to ultraviolet...

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Identifiers

PMID: 19452503
DOI: 10.1002/jcp.21804
PMCID: PMC2705480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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