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Article

Dimerization of the human melanocortin 1 receptor: functional consequences and dominant-negative effects.

The Journal of investigative dermatology - 1 Jan 2006

Sánchez-Laorden Berta L, Sánchez-Más Jesús, Martínez-Alonso Emma, Martínez-Menárguez José A, García-Borrón José C, Jiménez-Cervantes Celia

Abstract excerpt

The melanocortin 1 receptor (MC1R), a G(S)-protein-coupled receptor (GPCR), is a key regulator of proliferation and differentiation of epidermal melanocytes, and a determinant of human skin phototype and cancer risk. Homodimerization has been demonstrated for several GPCRs, but little information is available for MC1R. SDS-PAGE analysis of melanoma cells and heterologous cells expressing epitope-tagged MC1R...

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PMID: 16417234
DOI: 10.1038/sj.jid.5700036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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