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Article

Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma development and survival.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2009

Toffoli Giuseppe, Biason Paola, Russo Antonio, De Mattia Elena, Cecchin Erika, Hattinger Claudia Maria, Pasello Michela, Alberghini Marco, Ferrari Cristina, Scotlandi Katia, Picci Piero, Serra Massimo

Abstract excerpt

PURPOSE: The germ-line polymorphisms TP53 Arg72Pro and MDM2 SNP309 T>G are risk factors for tumor development and affect response to chemotherapy and survival in several cancers, but their prognostic and predictive value in patients with high-grade osteosarcomas is not yet defined. The purpose of this study was to investigate the effect of the TP53 Arg72Pro and the MDM2 SNP309 on the risk of osteosarcoma...

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Source

Identifiers

PMID: 19451596
DOI: 10.1158/1078-0432.CCR-08-2249

Genes

MDM2
EFS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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