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Article

Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet.

Journal of hepatology - 1 Jul 2009

Pogribny Igor P, Tryndyak Volodymyr P, Bagnyukova Tetyana V, Melnyk Stepan, Montgomery Beverly, Ross Sharon A, Latendresse John R, Rusyn Ivan, Beland Frederick A

Abstract excerpt

BACKGROUND/AIMS: The importance of epigenetic changes in etiology and pathogenesis of disease has been increasingly recognized. However, the role of epigenetic alterations in the genesis of hepatic steatosis and cause of individual susceptibilities to this pathological state are largely unknown. METHODS: Male inbred C57BL/6J and DBA/2J mice were fed a lipogenic methyl-deficient diet (MDD) that causes liver injury...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19450891
DOI: 10.1016/j.jhep.2009.03.021
PMCID: PMC2773516

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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