Article
Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2012
Tryndyak Volodymyr, de Conti Aline, Kobets Tetyana, Kutanzi Kristy, Koturbash Igor, Han Tao, Fuscoe James C, Latendresse John R, Melnyk Stepan, Shymonyak Svitlana, Collins Leonard, Ross Sharon A, Rusyn Ivan, Beland Frederick A, Pogribny Igor P
Abstract excerpt
Nonalcoholic fatty liver disease (NAFLD) is a major health problem and a leading cause of chronic liver disease in the United States and developed countries. In humans, genetic factors greatly influence individual susceptibility to NAFLD. The goals of this study were to compare the magnitude of interindividual differences in the severity of liver injury induced by methyl-donor deficiency among individual inbred...
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