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Article

Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 2006

Dumas Marc-Emmanuel, Barton Richard H, Toye Ayo, Cloarec Olivier, Blancher Christine, Rothwell Alice, Fearnside Jane, Tatoud Roger, Blanc Véronique, Lindon John C, Mitchell Steve C, Holmes Elaine, McCarthy Mark I, Scott James, Gauguier Dominique, Nicholson Jeremy K

Abstract excerpt

Here, we study the intricate relationship between gut microbiota and host cometabolic phenotypes associated with dietary-induced impaired glucose homeostasis and nonalcoholic fatty liver disease (NAFLD) in a mouse strain (129S6) known to be susceptible to these disease traits, using plasma and urine metabotyping, achieved by (1)H NMR spectroscopy. Multivariate statistical modeling of the spectra shows that the...

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Identifiers

PMID: 16895997
DOI: 10.1073/pnas.0601056103
PMCID: PMC1567909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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