Article
Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet.
Toxicology and applied pharmacology - 1 Jul 2012
Tryndyak Volodymyr P, Latendresse John R, Montgomery Beverly, Ross Sharon A, Beland Frederick A, Rusyn Ivan, Pogribny Igor P
Abstract excerpt
MicroRNAs (miRNAs) are a class of small, conserved, tissue-specific regulatory non-coding RNAs that modulate a variety of biological processes and play a fundamental role in the pathogenesis of major human diseases, including nonalcoholic fatty liver disease (NAFLD). However, the association between inter-individual differences in susceptibility to NAFLD and altered miRNA expression is largely unknown. In view of...
Topics
- Animals
- Biomarkers
- Choline Deficiency
- Disease Models, Animal
- Fatty Liver
- Folic Acid Deficiency
- Genetic Predisposition to Disease
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred Strains
- MicroRNAs