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Article

Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet.

Toxicology and applied pharmacology - 1 Jul 2012

Tryndyak Volodymyr P, Latendresse John R, Montgomery Beverly, Ross Sharon A, Beland Frederick A, Rusyn Ivan, Pogribny Igor P

Abstract excerpt

MicroRNAs (miRNAs) are a class of small, conserved, tissue-specific regulatory non-coding RNAs that modulate a variety of biological processes and play a fundamental role in the pathogenesis of major human diseases, including nonalcoholic fatty liver disease (NAFLD). However, the association between inter-individual differences in susceptibility to NAFLD and altered miRNA expression is largely unknown. In view of...

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Identifiers

PMID: 22561871
DOI: 10.1016/j.taap.2012.04.018
PMCID: PMC4281090

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