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Article

Cognitive appraisal and life stress moderate the effects of the 5-HTTLPR polymorphism on amygdala reactivity.

Human brain mapping - 1 Nov 2011

Lemogne Cédric, Gorwood Philip, Boni Claudette, Pessiglione Mathias, Lehéricy Stéphane, Fossati Philippe

Abstract excerpt

The short allele of the serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism is associated with increased amygdala activation in response to emotional stimuli. Although top-down processes may moderate this association, available evidence is conflicting, showing the genotype influence on amygdala reactivity to be either decreased or increased during emotion regulation. Because the effects of the...

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Identifiers

PMID: 21246665
DOI: 10.1002/hbm.21150
PMCID: PMC6870430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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