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Article

Cognitive appraisal and life stress moderate the effects of the 5-HTTLPR polymorphism on amygdala reactivity.

Human brain mapping - 1 Nov 2011

Lemogne Cédric, Gorwood Philip, Boni Claudette, Pessiglione Mathias, Lehéricy Stéphane, Fossati Philippe

Abstract excerpt

The short allele of the serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism is associated with increased amygdala activation in response to emotional stimuli. Although top-down processes may moderate this association, available evidence is conflicting, showing the genotype influe...

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Share to Amygdala
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21246665
DOI: 10.1002/hbm.21150
PMCID: PMC6870430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21246665-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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