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Article

CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo

29 Apr 2015

Abstract excerpt

Adoptive transfer of cytomegalovirus (CMV)-specific T cells derived from adult seropositive donors can effectively restore antiviral immunity after transplantation. However, CMV-seronegative donors lack CMV-specific memory T cells, which restricts the availability of virus-specific T cells for immunoprophylaxis. We demonstrate the feasibility of deriving CMV-specific T cells from naïve cells for T cell therapy....

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PMID: 25925682
DOI: 10.1126/scitranslmed.aaa2546

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