Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single channel study of deltamethrin interactions with wild-type and mutated rat Na(V)1.2 sodium channels expressed in Xenopus oocytes.

Neurotoxicology - 1 May 2009

Peng Fang, Mellor Ian R, Williamson Martin S, Davies T G Emyr, Field Linda M, Usherwood Peter N R

Abstract excerpt

Single channel analysis was used to compare the electrophysiological properties of wild-type (WT) and I874M mutant (M874) rat Na(V)1.2 channels expressed in Xenopus oocytes and their modulation by the pyrethroid deltamethrin. In the absence of pyrethroid, histograms of channel open times were best-fit by single exponentials. The open time constants at -40 mV for WT (0.53+/-0.05 ms) and M874 (0.65+/-0.08 ms)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electrophysiological Phenomena
Share to Insecticides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to NAV1.2 Voltage-Gated Sodium Channel

Share to Nitriles

Share to Pyrethrins

Share to Sodium Channels

Share to Xenopus laevis

Source

Identifiers

PMID: 19442819
DOI: 10.1016/j.neuro.2009.02.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single channel study of deltamethrin interactions with wild-type and mutated rat Na(V)1.2 sodium channels expressed in Xenopus oocytes.PMID 19442819Read ↗

Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin.Semantic proximity Read ↗

The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.Semantic proximity Read ↗

Batrachotoxin-resistant Na+ channels derived from point mutations in transmembrane segment D4-S6.Semantic proximity Read ↗

Mutations of the para sodium channel of Drosophila melanogaster identify putative binding sites for pyrethroids.Semantic proximity Read ↗

Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids.Semantic proximity Read ↗

Irreversible block of cardiac mutant Na+ channels by batrachotoxin.Semantic proximity Read ↗

Mammalian skeletal muscle voltage-gated sodium channels are affected by scorpion depressant "insect-selective" toxins when preconditioned.Semantic proximity Read ↗

An important role of a pyrethroid-sensing residue F1519 in the action of the N-alkylamide insecticide BTG 502 on the cockroach sodium channel.Semantic proximity Read ↗

Open probability of the epithelial sodium channel is regulated by intracellular sodium.Semantic proximity Read ↗

Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel.Semantic proximity Read ↗

Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids.Semantic proximity Read ↗

A residue in the transmembrane segment 6 of domain I in insect and mammalian sodium channels regulate differential sensitivities to pyrethroid insecticides.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.