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Article

Irreversible block of cardiac mutant Na+ channels by batrachotoxin.

Channels (Austin, Tex.) - 1 Jan 2000

Wang Sho-Ya, Tikhonov Denis B, Mitchell Jane, Zhorov Boris S, Wang Ging Kuo

Abstract excerpt

Batrachotoxin (BTX) not only keeps the voltage-gated Na(+) channel open persistently but also reduces its single-channel conductance. Although a BTX receptor has been delimited within the inner cavity of Na(+) channels, how Na(+) ions flow through the BTX-bound permeation pathway remains unclear. In this report we tested a hypothesis that Na(+) ions traverse a narrow gap between bound BTX and residue N927 at D2S6...

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Source

Identifiers

PMID: 18690024
DOI: 10.4161/chan.4437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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