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Article

Antisense-Mediated RNA Targeting: Versatile and Expedient Genetic Manipulation in the Brain

1 Jan 2011

Abstract excerpt

A limiting factor in brain research still is the difficulty to evaluate in vivo the role of the increasing number of proteins implicated in neuronal processes. We discuss here the potential of antisense-mediated RNA targeting approaches. We mainly focus on those that manipulate splicing (exon skipping and exon inclusion), but will also briefly discuss mRNA targeting. Classic knockdown of expression by mRNA...

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Share to Neurogenetic and Muscular Disorders Research
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Identifiers

PMID: 21811437
DOI: 10.3389/fnmol.2011.00010

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