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Article

FoxM1 Is a General Target for Proteasome Inhibitors

11 Aug 2009

Abstract excerpt

Proteasome inhibitors are currently in the clinic or in clinical trials, but the mechanism of their anticancer activity is not completely understood. The oncogenic transcription factor FoxM1 is one of the most overexpressed genes in human tumors, while its expression is usually halted in normal non-proliferating cells. Previously, we established that thiazole antibiotics Siomycin A and thiostrepton inhibit FoxM1...

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PMID: 19672316
DOI: 10.1371/journal.pone.0006593

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FoxM1 Is a General Target for Proteasome InhibitorsPMID 19672316Read ↗

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