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Article

Small molecule targeting FOXM1 DNA binding domain exhibits anti-tumor activity in ovarian cancer

9 Jun 2022

Abstract excerpt

FOXM1 is a potent oncogenic transcription factor essential for cancer initiation, progression, and drug resistance. FOXM1 regulatory network is a major predictor of adverse outcomes in various human cancers. Inhibition of FOXM1 transcription factor function is a potential strategy in cancer treatment. In this study, we performed structure-based in silico screening to discover small molecules targeting the FOXM1...

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PMID: 35680842
DOI: 10.1038/s41420-022-01070-w

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