Article
Identification of new SLE-associated genes with a two-step Bayesian study design.
Genes and immunity - 1 Jul 2009
Armstrong D L, Reiff A, Myones B L, Quismorio F P, Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Silverman E, Ojwang J O, Kaufman K M, Kelly J A, Merrill J T, Harley J B, Bae S-C, Vyse T J, Gilkeson G S, Gaffney P M, Moser K L, Putterman C, Edberg J C, Brown E E, Ziegler J, Langefeld C D, Zidovetzki R, Jacob C O
Abstract excerpt
In our earlier study, we utilized a Bayesian design to probe the association of approximately 1000 genes (approximately 10,000 single-nucleotide polymorphisms (SNPs)) with systemic lupus erythematosus (SLE) on a moderate number of trios of parents and children with SLE. Two genes associated with SLE, with a multitest-corrected false discovery rate (FDR) of <0.05, were identified, and a number of noteworthy genes...
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