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Article

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells.

The Journal of experimental medicine - 9 Jun 2008

Lochner Matthias, Peduto Lucie, Cherrier Marie, Sawa Shinichiro, Langa Francina, Varona Rosa, Riethmacher Dieter, Si-Tahar Mustapha, Di Santo James P, Eberl Gérard

Abstract excerpt

The nuclear hormone receptor retinoic acid receptor-related orphan receptor gamma t (RORgamma t) is required for the generation of T helper 17 cells expressing the proinflammatory cytokine interleukin (IL)-17. In vivo, however, less than half of RORgamma t(+) T cells express IL-17. We report here that RORgamma t(+) T alphabeta cells include Foxp3(+) cells that coexist with IL-17-producing RORgamma t(+) T...

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Identifiers

PMID: 18504307
DOI: 10.1084/jem.20080034
PMCID: PMC2413035

Genes

CCL20

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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