Article
Association between osteopontin and human abdominal aortic aneurysm.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2007
Golledge Jonathan, Muller Juanita, Shephard Neil, Clancy Paula, Smallwood Linda, Moran Corey, Dear Anthony E, Palmer Lyle J, Norman Paul E
Abstract excerpt
OBJECTIVES: In vitro and animal studies have implicated osteopontin (OPN) in the pathogenesis of aortic aneurysm. The relationship between serum concentration of OPN and variants of the OPN gene with human abdominal aortic aneurysm (AAA) was investigated. METHODS AND RESULTS: OPN genotypes were examined in 4227 subjects in which aortic diameter and clinical risk factors were measured. Serum OPN was measured by...
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