Osteoprotegerin is associated with reduced risk of abdominal aortic aneurysm and the role of vascular calcification: insights from Mendelian randomization approach.

doi:10.1016/j.numecd.2026.104607

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Article

Osteoprotegerin is associated with reduced risk of abdominal aortic aneurysm and the role of vascular calcification: insights from Mendelian randomization approach.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Jun 2026

Guo Xingzhi, Tian Ge, Zhou Rong, Hou Chen, Tang Peng, Li Rui

Abstract excerpt

BACKGROUND AND AIMS: Studies have suggested that osteoprotegerin (OPG) is implicated in modulating vascular calcification and is associated with the risk of aneurysms, but the causal relationships among them remain unclear. This Mendelian randomization (MR) study aims to investigate the causal effects of OPG on aneurysm risk and to explore the role of vascular calcification. METHODS AND RESULTS: Genetic variants...

Topics

Humans
Osteoprotegerin
Mendelian Randomization Analysis
Aortic Aneurysm, Abdominal
Vascular Calcification
Risk Factors
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Phenotype
Risk Assessment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aortic Aneurysm, Thoracic

Male

Intracranial Aneurysm

Protective Factors

Female

Middle Aged

Aged

Source

Open in PubMed

Identifiers

PMID: 41748418
DOI: 10.1016/j.numecd.2026.104607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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