Article
A single nucleotide polymorphism in the promoter region of the human gene for osteoprotegerin is related to vascular morphology and function.
Biochemical and biophysical research communications - 26 Apr 2002
Brändström Helena, Stiger Fredrik, Lind Lars, Kahan Thomas, Melhus Håkan, Kindmark Andreas
Abstract excerpt
Osteoprotegerin (OPG) is a secreted member of the tumor necrosis factor receptor family, and has previously been shown to regulate bone mass by inhibiting osteoclast differentiation and activation. Recent evidence indicates that OPG also plays a role in the vascular system, since ablation of the OPG gene in mice results in calcification of the aorta and renal arteries, and association has been found between serum...
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