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Article

Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancer.

Cancer research - 15 May 2009

DeMichele Angela, Gray Robert, Horn Michelle, Chen Jinbo, Aplenc Richard, Vaughan William P, Tallman Martin S

Abstract excerpt

Interleukin-6 modulates immune response, estrogen production, and growth pathways in breast cancer. We evaluated the effect of several common, functional interleukin-6 promoter variants in node-positive breast cancer patients enrolled on a multicenter, cooperative group, adjuvant chemotherapy trial to determine whether these variants were associated with clinical outcome overall and by estrogen receptor tumor...

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Identifiers

PMID: 19435922
DOI: 10.1158/0008-5472.CAN-08-2989
PMCID: PMC4304767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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